Characterization of hospitalized patients with infections caused by nontuberculous mycobacteria, in a highly complex hospital in Colombia

Characterization of hospitalized patients with infections caused by nontuberculous mycobacteria, in a highly complex hospital in Colombia

Drag. Luz Eugenia Pérez
Franco E. Montufar Andrade, Camilo A. Madrid Munoz , Juan P. Villa Franco
Infection
Publication date: 07/2014

Summary:

Background:

Nontuberculous mycobacterial infections (MNT) are described more frequently in recent years, especially in immunosuppressed patients and in patients treated for cosmetic procedures. MNTs include species of the genusMycobacterium, different from the complexMycobacterium tuberculosis andMycobacterium leprae.

objective:

Describe the demographic and clinical characteristics of hospitalized patients with NTM infections..

Methodology:

Retrospective descriptive study.

Results:

From 187 culture-documented mycobacterial infection patients, 17 (9,1%) had NTM infection. Average age of 38.4 ± 19.2 years. He 58,82% they were men. The main comorbidities were HIV / AIDS (41,17%), Mellitus diabetes (23,53%), chronic kidney disease (17,64%), immunosuppressive therapy (17,64%) and neoplasms (17,64%). In those coinfected with HIV, the CD4 count was <50 in 85,71%. The most frequent species were complexM. avium (CMA) 35,29%, M. abscessus (17,65%) andM. chelonae (11,76%). The forms of infection were: scattered (35,29%), pulmonary (23,53%), skin and soft tissues (17,64%) and gastrointestinal (11,76%). Average stay of 22,1 days; a 23,53% required ICU care. Overall mortality was 23,53%.

conclusion:

NTM infections cause a number of pathological conditions, immunocompromised patients are the population at greatest risk and disseminated and pulmonary forms, the most frequent. Early suspicion as well as taking adequate samples and the use of appropriate diagnostic methods are essential for its timely diagnosis and adequate treatment..

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