Coinfection by human immunodeficiency virus and mycobacteria in a highly complex university hospital in Colombia

Coinfection by human immunodeficiency virus and mycobacteria in a highly complex university hospital in Colombia

Drag. Luz Eugenia Pérez
Franco Eduardo Montufar, María Alejandra Monsalve, Luz Eugenia Pérez, Maria Camila Montufar
Infection
Publication date: 12/2016

Summary:

Background: Human immunodeficiency virus coinfection (VIH) and mycobacteria has a dual effect; the risk of extrapulmonary and disseminated mycobacterial disease is increased and the progression of HIV disease is accelerated. The tuberculosis (TB) it is the most life-threatening entity in these patients.

Methodology: Observational study, descriptive, retrospective.

objective: Determine the epidemiological characteristics, Clinical signs and resistance profile in patients with HIV and mycobacterial coinfection.

Results: From 159 patients diagnosed with HIV infection, 44 (27,7%) they had mycobacterial coinfection. The average age was 36,7 years ± 11.3. He 86% they were men. Upon admission 66% had acquired immune deficiency syndrome (PAGE), 20% history of TB and 11% history of other sexually transmitted diseases. He 50% had CD4 T cells <50/mm3. The main comorbidities were hematological neoplasms 11%, heart failure 4,5% and lymphoproliferative disease 4,5%. The annual incidence was 4,6%. The disseminated forms were the 54% of the cases. Was identifiedM. tuberculosis in 77,3%, non-tuberculous mycobacteria (MNT) in 18,3% and in the 4,5% it was not possible to establish the species. He 2,5% of the isolates ofM. tuberculosis they were multi-drug resistant (TB-MDR) and in 18,2% single drug resistance or combined resistance identified. At 54% of patients lung involvement was documented. The fatality was 9,1%.

conclusion: In our patients, infection byM. tuberculosis It is the most frequent and the high prevalence of resistance to at least one drug and MDR-TB is striking.. NTM infections are becoming more common. The disseminated and extrapulmonary forms are very important. Annual incidence is high.

%d bloggers like this: